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KMID : 1134820190480020179
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Journal of the Korean Society of Food Science and Nutrition
2019 Volume.48 No. 2 p.179 ~ p.188
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Effect of Lactobacillus acidophilus YT1 on Serum Lipid and Bone Formation in Ovariectomized Rats
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Lee Min-Hee
Yun Jeong-Moon
Park Soo-Jeung
Kim Da-Kyung
Kim Ok-Kyung
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Abstract
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This study was undertaken to determine the effect of Lactobacillus acidophilus YT1 on serum lipid levels and bone formation in ovariectomized rats. Animals were randomly allocated seven groups; the normal control (NC), the sham-operated control (Sham), the ovariectomized (OVX), the OVX+1 mg/kg body weight (b.w.) of estradiol (OVX+PC), the OVX+1×106 CFU/kg b.w. of L. acidophilus YT1 (OVX+Low), the OVX+1×107 CFU/kg b.w. of L. acidophilus YT1 (OVX+Medium), and the OVX+1×108 CFU/kg b.w. of L. acidophilus YT1 (OVX+High) groups. All rats were provided with supplemented experimental diets and water for 8 weeks. Body weight gain, food efficiency rate, and abdominal temperatures were significantly lower in the OVX+PC, OVX+L. acidophilus groups (OVX+Low, OVX+Medium, and OVX+High groups) than in the OVX group. Serum lipid content analysis showed that the total cholesterol, triglyceride, and low density lipoprotein cholesterol levels were significantly lower in the OVX+PC, and OVX+L. acidophilus groups than in the OVX group, whereas high density lipoprotein cholesterol levels in the OVX group and the other groups were not significantly different. Serum estradiol levels were significantly lower in the OVX group than in the NC and Sham groups, but L. acidophilus supplementation had no observed effect on serum estradiol levels. Bone morphometric markers (BMD, BV/TV, Tb.N) were significantly higher in the OVX+PC and OVX+High groups than in the OVX group. In addition, L. acidophilus supplementation increased the mRNA expression of ER2 and OPG, and decreased the mRNA expression of RANKL in tibia as compared with those observed in the OVX group. These results suggest L. acidophilus YT1 might offer a means of ameliorating menopause associated symptoms such as osteoporosis, dyslipidemia, and face flushing.
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KEYWORD
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Lactobacillus acidophilus YT1, ovariectomized, ER2, bone density, estradiol
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